α-Hydroxyfarnesylphosphonic acid |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | Farnesylation / Isoprenylation Reagents |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-290-009-M001 |
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1 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C15H27O4P |
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| MW: | 302.4 |
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| PURITY: | ≥96% |
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| FORMULATION: | Liquid. 1mg dissolved in 500µl ethanol. |
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| SOLUBILITY: | Soluble in DMSO or 100% ethanol. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Product decomposes rapidly when not in solution. Do not evaporate to dryness. |
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| Product Description |
Potent inhibitor of farnesyltransferase in cell-free enzyme preparations (IC50=30nM) and in whole cells. Selectively inhibits farnesyltransferase over geranylgeranyltransferases I and II (IC50=35.8µM and IC50=67.0µM). |
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| | Product Specific Literature References | Steady-state kinetic mechanism of Ras farnesyl:protein transferase: D.L. Pompliano, et al.; Biochemistry 31, 3800 (1992) Abstract
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo: J.B. Gibbs, et al.; J. Biol. Chem. 268, 7617 (1993) Full Text; http://www.jbc.org/cgi/reprint/268/11/7617.pdf
Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review) Abstract |
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