α-Amanitin |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Other Natural Products - DNA Regulation / Transcription |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-270-M001 |
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1 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C39H54N10O14S |
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| MW: | 919.0 |
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| CAS NUMBER: | 23109-05-9 |
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| MERCK INDEX: | 14: 373 |
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| RTECS: | BD6195000 |
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| SOURCE/HOST: | Isolated from Amanita phalloides mushrooms. |
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| PURITY: | ≥90% |
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| APPEARANCE: | White to light yellow powder. |
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| SOLUBILITY: | Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base. |
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| HANDLING: | Protect from light. |
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| HAZARD: | VERY TOXIC. |
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| Product Description |
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis. |
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| | Product Specific Literature References | Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967) Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970) Abstract
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review) Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004) Abstract |
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| RELATED PRODUCT GROUPS |
Natural Products / Antibiotics > Toxins > Amanitins & Phalloidins / Related Products / DNA Regulation / Transcription > RNA Polymerases / Related Products / Protein Synthesis, Modification & Degradation > Protein Synthesis > Protein Synthesis Other Products |
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