α-Conotoxin GI |
 |
| PRODUCT LINE | Natural Products / Antibiotics |
|
|
| PRODUCT FAMILIES | Neurotoxins |
|
|
|
| Ordering Information |
|
| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-630-046-C500 |
|
500 µg | | | | | | |
|
|
| Product Specification |
|
|
| SEQUENCE: | H-Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2 . HCl
(Disulfide bonds between Cys2-Cys7and Cys3-Cys13) |
|
|
| |
|
| FORMULA: | C55H80N20O18S4 |
|
|
| |
|
| MW: | 1437.6 |
|
|
| |
|
| RTECS: | GL1500000 |
|
|
| |
|
| SOURCE/HOST: | Synthetic. Originally isolated from Conus geographus. |
|
|
| |
|
| PURITY: | ≥97% |
|
|
| |
|
| APPEARANCE: | White amorphous powder. |
|
|
| |
|
| SOLUBILITY: | Soluble in water. |
|
|
| |
|
| SHIPPING: | AMBIENT |
|
|
| |
|
| LONG TERM STORAGE: | -20°C |
|
|
| |
|
| HAZARD: | VERY TOXIC. |
|
|
|
|
| Product Description |
Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A. |
|
| | Product Specific Literature References | Peptide toxins from Conus geographus venom: W.R. Gray, et al.; J. Biol. Chem. 256, 4734 (1981) Abstract
Primary and secondary structure of conotoxin GI, a neurotoxic tridecapeptide from a marine snail: Y. Nishiuchi & S. Sakakibara; FEBS Lett. 148, 260 (1982) Abstract
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994) Abstract
alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review) Abstract
Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review) Abstract
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review) Abstract |
|
|
|
|
| RELATED PRODUCT GROUPS |
Peptides / Neurobiology > Acetylcholine & Acetylcholine Receptors > Acetylcholine Receptors / Related Products > Acetylcholine Receptors Other Products / Natural Products / Antibiotics > Natural Products > Marine Natural Products |
|
|
|
