α-Conotoxin MI |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Neurotoxins |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-630-048-C500 |
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500 µg | | | | | | |
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| Product Specification |
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| SEQUENCE: | H-Gly-Arg-Cys-Cys-His-Pro-Ala-Cys-Gly-Lys-Asn-Tyr-Ser-Cys-NH2
(Disulfide bonds between Cys3-Cys8and Cys4-Cys14) |
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| FORMULA: | C58H86N22O17S4 |
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| MW: | 1491.7 |
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| SOURCE/HOST: | Synthetic. Originally isolated from Conus magus. |
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| PURITY: | ≥97% |
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| APPEARANCE: | Lyophilized. |
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| SOLUBILITY: | Soluble in water. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HAZARD: | VERY TOXIC. |
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| Product Description |
Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A. |
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| | Product Specific Literature References | Isolation and structure of a peptide toxin from the marine snail Conus magus: M. McIntosh, et al.; Arch. Biochem. Biophys. 218, 329 (1982) Abstract
Synthesis of conotoxin MI and GII: structure-activity relationship of conotoxins: Y. Nishiuchi & S. Sakakibara; Peptide Chemistry (Edited by E. Munekata) Protein Research Foundation, Osaka 1983, 191 (1984)
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994) Abstract
alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review) Abstract
Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review) Abstract
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review) Abstract |
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| RELATED PRODUCT GROUPS |
Peptides / Neurobiology > Acetylcholine & Acetylcholine Receptors > Acetylcholine Receptors / Related Products > Acetylcholine Receptors Other Products / Natural Products / Antibiotics > Natural Products > Marine Natural Products |
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