α-Conotoxin SI |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Neurotoxins |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-630-049-C500 |
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500 µg | | | | | | |
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| Product Specification |
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| SEQUENCE: | H-Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH2
(Disulfide bonds between Cys2-Cys7and Cys3-Cys13) |
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| FORMULA: | C55H83N16O16S4 |
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| MW: | 1352.6 |
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| SOURCE/HOST: | Synthetic. Originally isolated from Conus striatus. |
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| PURITY: | ≥96% |
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| APPEARANCE: | Lyophilized. |
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| SOLUBILITY: | Soluble in water. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HAZARD: | VERY TOXIC. |
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| Product Description |
Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A. |
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| | Product Specific Literature References | Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI: G.C. Zafaralla, et al.; Biochemistry 27, 7102 (1988) Abstract
Synthesis of .alpha.-conotoxin SI, a bicyclic tridecapeptide amide with two disulfide bridges: illustration of novel protection schemes and oxidation strategies: M.C. Munson & G. Barany; JACS 115, 10203 (1993)
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994) Abstract
alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review) Abstract
Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review) Abstract
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review) Abstract |
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| RELATED PRODUCT GROUPS |
Peptides / Neurobiology > Acetylcholine & Acetylcholine Receptors > Acetylcholine Receptors / Related Products > Acetylcholine Receptors Other Products / Natural Products / Antibiotics > Natural Products > Marine Natural Products |
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