This is a rabbit polyclonal antibody against ESR2. It was validated on Western Blot by Aviva Systems Biology.
| PRODUCT PROPERTIES |
| Host: | | Rabbit |
| Isotype: | | IgG |
| Immunogen: | | The immunogen for anti-ESR2 antibody: synthetic 67 directed towards the N terminal of human ESR2 |
| UniProt ID: | | Q8C5D8 |
| Species reactivity: | | Mouse
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| Specificity: | | Directed towards isoforms 1-8. |
| Applications: | | WB
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| Appearance: | | Lyophilized powder |
| Reconstitution: | | Add 100 µl of distilled water. Final anti-ESR2 antibody concentration is 1 mg/ml in PBS buffer. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.Pias2 plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.Pias2 binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
