This is a rabbit polyclonal antibody against ZNFN1A1. It was validated on Western Blot and immunohistochemistry by Aviva Systems Biology.
|Immunogen:||The immunogen for anti-ZNFN1A1 antibody: synthetic 67 directed towards the middle region of human ZNFN1A1|
|Reconstitution:||Add 50 µl of distilled water. Final anti-ZNFN1A1 antibody concentration is 1 mg/ml in PBS buffer.|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal 67 sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene|
|Background / Technical Information:||http://www.uniprot.org/uniprot/P21754-2 ||