This is a rabbit polyclonal antibody against KCNK13. It was validated on Western Blot by Aviva Systems Biology.
| PRODUCT PROPERTIES |
| Appearance: | | Lyophilized powder |
| Host: | | Rabbit |
| Isotype: | | IgG |
| Immunogen: | | The immunogen for anti-KCNK13 antibody: synthetic 67 directed towards the C terminal of human KCNK13 |
| UniProt ID: | | P39748 |
| Species reactivity: | | Human
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| Applications: | | WB
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| Reconstitution: | | Add 100 µl of distilled water. Final anti-KCNK13 antibody concentration is 1 mg/ml in PBS buffer. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
