This is a rabbit polyclonal antibody against HNRPA1. It was validated on Western Blot and immunohistochemistry by Aviva Systems Biology.
| PRODUCT PROPERTIES |
| Immunogen: | | The immunogen for anti-HNRPA1 antibody: synthetic 67 directed towards the N terminal of human HNRPA1 |
| UniProt ID: | | P49711 |
| Source: | | Rabbit |
| Species reactivity: | | Human, Mouse, Rat
Bovine, Chicken, Dog
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| Applications: | | IHC, WB
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| Appearance: | | Lyophilized powder |
| Reconstitution: | | Add 100 µl of distilled water. Final anti-HNRPA1 antibody concentration is 1 mg/ml in PBS buffer. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
