This is a rabbit polyclonal antibody against FGA. It was validated on Western Blot and immunohistochemistry by Aviva Systems Biology.
|Immunogen:||The immunogen for anti-FGA antibody: synthetic 67 directed towards the N terminal of human FGA|
|Species reactivity:||Human, Mouse, Rat|
|Reconstitution:||Add 100 µl of distilled water. Final anti-FGA antibody concentration is 1 mg/ml in PBS buffer.|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.|
|Background / Technical Information:||http://www.uniprot.org/uniprot/Q12986-2||