This is a rabbit polyclonal antibody against PRPF19. It was validated on Western Blot by Aviva Systems Biology.
|Immunogen:||The immunogen for anti-PRPF19 antibody: synthetic 67 directed towards the N terminal of human PRPF19|
|Reconstitution:||Add 100 µl of distilled water. Final anti-PRPF19 antibody concentration is 1 mg/ml in PBS buffer.|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.|
|Background / Technical Information:||http://www.uniprot.org/uniprot/P55895||