Rp-8-Br-PET-cGMPS

Membrane-permeant and PDE-resistant PKG inhibitor



BLG-P007-01	1 µmol	139.00 USD

Competitive inhibitor of protein kinase G type I alpha and I beta and of cGMP-gated retinal type ion channels (cyclic GMP antagonist). Resistant against mammalian cyclic nucleotide- dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane permeant compared to Rp-8-pCPT-cGMPS (Prod. No. BLG-C013).

PRODUCT PROPERTIES
Alternative Name:		β-Phenyl-1,N²-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate . sodium salt, Rp-isomer
Formula:		C₁₈H₁₄BrN₅O₆PS . Na
MW:		562.3
CAS:		172806-20-1
Quantity:		1µmol=~0.6mg
Purity:		> 99% HPLC
Appearance:		Lyophilized or crystallized sodium salt.
Solubility:		Limited solubility in water or buffer.
Reconstitution:		Rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Long Term Storage:		-20°C
Background / Technical Information:		For the Original Manufacturer's data sheet please click here.

Formula:

TECHNICAL DOCUMENTS Print as PDF	RELATED PRODUCTS No related products available
PRODUCT SUPPORT Technical Service Bulk Quantity Quote Customer Service	CATALOG SECTION cGMP-dependent Protein Kinase [PKG] cGMP-dependent Protein Kinase [PKG] cGMP-dependent Protein Kinase [PKG]

Product Literature References

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial: C. Zaragoza, et al.; Mol. Pharmacol. 62, 927 (2002), Abstract;

Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins: Y. Gao & J. Usha Raj; Eur. J. Pharmacol. 436, 227 (2002), Abstract;

Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling: C. Ibarra-Alvarado, et al.; Mol. Pharmacol. 61, 312 (2002), Abstract; Full Text

Rp-8-Br-PET-cGMPS

TECHNICAL DOCUMENTS

RELATED PRODUCTS

PRODUCT SUPPORT

CATALOG SECTION

Product Literature References