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Rp-8-Br-PET-cGMPS

Membrane-permeant and PDE-resistant PKG inhibitor
 
BLG-P007-01 1 µmol 139.00 USD
 
Competitive inhibitor of protein kinase G type I alpha and I beta and of cGMP-gated retinal type ion channels (cyclic GMP antagonist). Resistant against mammalian cyclic nucleotide- dependent phosphodiesterases, no metabolic side effects. More lipophilic and membrane permeant compared to Rp-8-pCPT-cGMPS (Prod. No. BLG-C013).
PRODUCT PROPERTIES
Alternative Name:β-Phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate . sodium salt, Rp-isomer
Formula:C18H14BrN5O6PS . Na
MW:562.3
CAS:172806-20-1
Quantity:1µmol=~0.6mg
Purity:> 99% HPLC
Appearance:Lyophilized or crystallized sodium salt.
Solubility:Limited solubility in water or buffer.
Reconstitution:Rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing.
Long Term Storage:-20°C
Background / Technical Information:For the Original Manufacturer's data sheet please click here.
Formula:
BLG-P007

TECHNICAL DOCUMENTS

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CATALOG SECTION

cGMP-dependent Protein Kinase [PKG]
cGMP-dependent Protein Kinase [PKG]
cGMP-dependent Protein Kinase [PKG]

Product Literature References

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial: C. Zaragoza, et al.; Mol. Pharmacol. 62, 927 (2002), Abstract;
Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins: Y. Gao & J. Usha Raj; Eur. J. Pharmacol. 436, 227 (2002), Abstract;
Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling: C. Ibarra-Alvarado, et al.; Mol. Pharmacol. 61, 312 (2002), Abstract; Full Text
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