| PRODUCT PROPERTIES |
| Alternative Name: | | VIP |
| Clone: | | 2 |
| Host: | | Mouse |
| Isotype: | | IgG1κ |
| Immunogen: | | Vasoactive intestinal peptide. |
| UniProt ID: | | P01282 |
| Species reactivity: | | Human, Rat
Bovine, Porcine
|
| Applications: | | ELISA, WB
|
| Application Notes: | | Detects a band of ~3kDa by Western blot. |
| Purity Detail: | | Protein A/G-affinity purified. |
| Formulation: | | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
| Short Term Storage: | | +4°C |
| Miscellaneous/General: | | Vasoactive intestinal peptide (VIP) is a 28-amino-acid peptide belonging to the secretin-glucagon family of peptide hormones. Its sequence is identical in man, ox, pig and rat. VIP is widely distributed in the central and peripheral nervous systems, acting as a neurotransmitter or neuromodulator. Peripherally it is involved in vaso- and bronchodilatation, smooth muscle relaxation and stimulation of secretion. Ectopic endocrine tumors secreting VIP (VIPomas) lead to raised plasma levels of VIP and are associated with watery diarrhea, hypokalemia and achlorhydria syndrome. VIP shows high sequence homology with peptide histidine-methionine (PHM) in man or peptide histidine-serine (PHI) in pigs or rats, present in the same precursor, and with the neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP). |
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RELATED LITERATURE
Essential Research Tools for Neurodegeneration & Neural Signaling
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