Caspase-1 is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20kDa) and small (10kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.
The active recombinant human caspase-1 was expressed in E.
|Alternative Name:||Interleukin 1β Converting Enzyme (active) (human) (recombinant), IL-1β Converting Enzyme (active) (human) (recombinant), ICE (active) (human) (recombinant)|
|Long Term Storage:||-80°C|
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.