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Caspase-6 (active) (human) (recombinant)

A cysteine-aspartic acid protease involved in apoptosis
 
BV-1086-25 25 U 226.00 USD
 
BV-1086-100 100 U 385.00 USD
 

Caspase-6 is a member of the caspase-family of cysteine proteases. Similar to other caspases, caspase-6 also exists in cells as an inactive proenzyme. During apoptosis procaspase-6 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-6 consists of large (18 kDa) and small (11 kDa) subunits which associate to form the active enzyme. Active caspase-6 has been shown involving in the proteolysis of PARP (poly ADP-ribose polymerase), an enzyme that is involved in DNA repair and genomic maintenance.
The active recombinant human caspase-6 was expressed in E.

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coli. The active rhcaspase-6 is routinely tested at BioVision for its ability to enzymatically cleave the two substrates Ac-VEID-pNA (Prod. No. BV-1070) or Ac-VEID-AFC (Prod. No. BV-1069).
Active rhcaspase-6 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays.

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PRODUCT PROPERTIES
MW:large (18 kDa) and small (11 kDa)
Source:E. coli.
UniProt ID:P55212
Formulation:Lyophilized powder
Purity:≥95%
Specific Activity:13,000units/mg.
Long Term Storage:-80°C
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

TECHNICAL DOCUMENTS

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