Caspase-7 (also known as Mch3, ICE-LAP3, CMH-1) is a member of the interleukin-1β converting enzyme (ICE) family of cysteine proteases. Same as other caspases, caspase-7 also exists in cells as an inactive proenzyme. During apoptosis procaspase-7 is processed at aspartate residues by self-protolysis and/or cleavage by another caspase. The processed form of caspase-7 consists of large and small subunits which associate to form the active enzyme. The active caspase-7 has been shown involving in the proteolysis of poly(ADP-ribose) polymerase (PARP), an enzyme that is involved in DNA repair and genomic maintenance.
|Long Term Storage:||-80°C|
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