Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.
PRODUCT PROPERTIES |
Formula: | | C16H15NO7S |
MW: | | 365.36 |
CAS: | | 501919-59-1 |
Purity: | | ≥97% by HPLC |
Appearance: | | Off-white solid |
Solubility: | | DMSO (10 mg/ml) |
Long Term Storage: | | -20°C |
Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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