Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC₅₀'s at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.
| PRODUCT PROPERTIES |
| Alternative Name: | | 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone |
| Formula: | | C₁₉H₂₃F₂N₅O₂ |
| MW: | | 391.42 |
| CAS: | | 501437-28-1 |
| Purity: | | ≥98% by TLC |
| Appearance: | | Pale orange solid |
| Solubility: | | DMSO (>25 mg/ml) |
| Long Term Storage: | | -20°C |
| Handling: | | Protect from light. Protect from air. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
