United States
BI-D1870
An ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK)
| BV-1924-1 | 1 mg | 94.00 USD |  |
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| BV-1924-5 | 5 mg | 325.00 USD | |
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Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.
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