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BI-D1870

An ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK)
 
BV-1924-1 1 mg 94.00 USD
 
BV-1924-5 5 mg 325.00 USD
 
Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations.  In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.
PRODUCT PROPERTIES
Alternative Name:2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Formula:C19H23F2N5O2
MW:391.42
CAS:501437-28-1
Purity:≥98% by TLC
Appearance:Pale orange solid
Solubility:DMSO (>25 mg/ml)
Long Term Storage:-20°C
Handling:Protect from light. Protect from air.
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

TECHNICAL DOCUMENTS

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CATALOG SECTION

Ribosomal Protein S6 Kinase
Ribosomal Protein S6 Kinase
Ribosomal Protein S6 Kinase
Ribosomal Protein S6 Kinase
Ribosomal Protein S6 Kinase
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