A cell-permeable inhibitor of the ubiquitin-specific protease (IC50 = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀>50 µM) towards a panel of 14 isopeptidases and other proteases. Inhibits USP7-mediated p53 deubiquitination.
PRODUCT PROPERTIES |
Formula: | | C12H7F2NO3S2 |
MW: | | 315.32 |
Appearance: | | Yellow solid |
CAS: | | 1247819-59-5 |
Solubility: | | DMSO (~ 30 mg/ml) |
Purity: | | ≥98% by HPLC |
Long Term Storage: | | -20°C |
Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
|
|
|