|Alternative Name:||Interleukin-1β convertase, IL-1BC, p45, IL1B-convertase, CASP-1, ICE|
|Immunogen:||Synthetic peptide surrounding amino acid 132 of human caspase-1 |
|Species reactivity:||Human, Mouse, Rat|
|Purity Detail:||Affinity Purified Antibody|
30 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
|Handling:||The antibody solution should be gently mixed before use.|
|Short Term Storage:||-20°C|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis. |
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.