PRODUCT PROPERTIES |
Alternative Name: | | CASP-11, ICEB, ICH-3 |
Host: | | Rabbit |
Isotype: | | IgG |
Immunogen: | | Synthetic peptide surrounding amino acid 257 of rat caspase-11 |
Species reactivity: | | Mouse, Rat
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Applications: | | WB
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Application Notes: | | The antibody detects procaspase-11 (45 kDa), a partially cleaved fragment (30 kDa) and fully cleaved fragment (20 kDa). A 58 kDa unknown identity band was also detected in 3T3 cells. |
Purity Detail: | | Affinity purified |
Concentration: | | 0.2 mg/ml |
Appearance: | | Colorless liquid |
Formulation: | | Liquid. In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling: | | Avoid freeze/thaw cycles. |
Short Term Storage: | | -20°C |
Long Term Storage: | | -20°C |
Miscellaneous/General: | | Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-11 is also synthesized as inactive pro-enzyme that are processed in cells undergoing apoptosis or inflammation. The processed form of caspase-11 consists of large and small subunits which associate to form an active enzyme. |
Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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