|Immunogen:||Synthetic peptide corresponding to residues surrounding amino acid 221 of human Granzyme B|
|Species reactivity:||Human, Mouse, Rat|
|Purity Detail:||Affinity Purified Antibody|
|Formulation:||100 µg (0.5 mg/ml) affinity purified polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||Granzyme B is a 27 kDa serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. |
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.