100 µg of affinity purified rabbit Bnip3L/Nix polyclonal antibody. Reacts with human/mouse. Tested in Western blotting and Immunohistochemistry.
|Alternative Name:||BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, NIP3-like protein X|
|Immunogen:||Synthetic peptide surrounding amino acid 80 of human Bnip3L.|
|Gene/Protein Identifier:||665 (GeneID)|
|Species reactivity:||Human, Mouse|
|Purity Detail:||Affinity Purified Antibody|
|Formulation:||100 µg (0.5 mg/ml) affinity purified rabbit anti-Bnip3L polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal.|
|Long Term Storage:||-20°C|
|Miscellaneous/General:||Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3α, and Nix (for Nip3-like protein X). Bnip3L/Bnip3α/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins.|
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.