| PRODUCT PROPERTIES |
| Host: | | Rabbit |
| Isotype: | | IgG |
| Immunogen: | | Synthetic peptide surrounding amino acid 162 of mouse alpha-Fodrin |
| UniProt ID: | | P16546 |
| Species reactivity: | | Human
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| Applications: | | IHC, WB
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| Purity Detail: | | Affinity purified |
| Concentration: | | 0.5 mg/ml |
| Appearance: | | Colorless liquid |
| Formulation: | | Liquid. In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of α- and β-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. α-Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N-terminal 150 kDa, C-terminal 120 kDa, and 35 kDa major products. Cleavage of α-Fodrin leads to membrane malfunction and cell shrinkage. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
