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BMF polyclonal antibody

 
BV-3334R-30T 30 µg 98.00 USD
 
BV-3334R-100 100 µg 270.00 USD
 
PRODUCT PROPERTIES
Alternative Name:BMF, Bcl-2-modifying factor
Host:Rabbit
Isotype:IgG
Immunogen:Synthetic peptide surrounding amino acid 9 of human BMF
UniProt ID:Q96LC9
Species reactivity:Human, Mouse, Rat
Applications:IHC, WB
Application Notes:The antibody recognizes ~28 kDa BMF in sample from human, mouse and rat origins.
Purity Detail:Affinity purified
Concentration:0.5 mg/ml
Appearance:Colorless liquid
Formulation:Liquid. In phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling:After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.
Long Term Storage:-20°C
Miscellaneous/General:Bmf (for Bcl-2-modifying factor) is a novel BH3-only protein recently identified in human and mouse. The BH3 domain in Bmf is required for both binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptosis program.
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

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