| PRODUCT PROPERTIES |
| Alternative Name: | | BMF, Bcl-2-modifying factor |
| Appearance: | | Colorless liquid |
| Host: | | Rabbit |
| Isotype: | | Rabbit IgG |
| Immunogen: | | Synthetic peptide surrounding amino acid 9 of human BMF |
| Species reactivity: | | Human, Mouse, Rat
|
| Applications: | | WB
|
| Application Notes: | | The antibody recognizes ~28 kDa BMF in sample from human, mouse and rat origins. |
| Purity Detail: | | Affinity Purified Antibody |
| Concentration: | | 0.5 mg/ml |
| Formulation: | | 100 µg (0.5 mg/ml) affinity purified rabbit anti-BMF polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Handling: | | After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | Bmf (for Bcl-2-modifying factor) is a novel BH3-only protein recently identified in human and mouse. The BH3 domain in Bmf is required for both binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptosis program. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
|
|
|
United States
