|Immunogen:||Synthetic peptide surrounding amino acid 31 of human Wnt-1 |
|Application Notes:||The antibody recognizes 41kDa of human Wnt-1.|
|Purity Detail:||Affinity Purified Antibody|
|Formulation:||100 µg (0.5 mg/ml) affinity purified rabbit Wnt-1 polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
|Long Term Storage:||-20°C|
|Miscellaneous/General:||Wnt gene family members, including Wnt-1 through Wnt-10, play a key role in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue. Wnt-3 is also involved in tumorigenesis and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue. Wnt-1, Wnt-3 and Wnt-10b have been implicated along with FGF-3 in the development of mouse mammary tumor virus induced mouse mammary carcinomas. |
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.