| PRODUCT PROPERTIES |
| Alternative Name: | | Transcription factor A (mitochondrial), mtTFA, Transcription factor 6, TCF-6 |
| Appearance: | | Colorless liquid |
| Host: | | Rabbit |
| Isotype: | | Rabbit IgG |
| Immunogen: | | Synthetic peptide corresponding to residues surrounding amino acid 225 of rat TFAM |
| Species reactivity: | | Rat
|
| Applications: | | WB
|
| Application Notes: | | The antibody recognizes 27 kDa band from rat kidney tissue lysate. |
| Purity Detail: | | Affinity Purified Antibody |
| Concentration: | | 0.5 mg/ml |
| Formulation: | | 100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | Transcription factor A mitochondria (TFAM) is an important activator of mitochondrial DNA transcription and replication. Studies in mice have shown that TFAM is required to regulate the mitochondrial genome copy number and is important for embryonic development. TFAM has been associated with mitochondrial disorder which includes ocular myopathy and muscular wasting in humans. Kearns-Sayre syndrome was shown in mouse model when expression of the gene was eliminated by targeted disruption in heart and muscle cells. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
United States
