| PRODUCT PROPERTIES |
| Alternative Name: | | Transforming growth factor beta 2 |
| Host: | | Rabbit |
| Isotype: | | IgG |
| Immunogen: | | Synthetic peptide surrounding amino acid 366 of human TGF-β2 |
| Species reactivity: | | Human, Mouse, Rat
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| Applications: | | WB
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| Application Notes: | | The antibody recognizes ~25kDa TGF-β2 of human, mouse, and rat origins. |
| Purity Detail: | | Affinity purified |
| Concentration: | | 0.5 mg/ml |
| Appearance: | | Colorless liquid |
| Formulation: | | Liquid. In phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. |
| Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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United States
