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PF-04217903

A novel ATP-competitive c-Met kinase inhibitor
 
BV-B2062-5 5 mg 127.00 USD
 
BV-B2062-25 25 mg 501.00 USD
 
PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903 inhibits tumor cell proliferation, survival, migration/invasion in MET-amplified cell lines in vitro and shows marked antitumor activity in tumor models harboring either MET gene amplification or a hepatocyte growth factor (HGF)/c-Met autocrine loop at well-tolerated dose levels in vivo.
PRODUCT PROPERTIES
Formula:C19H16N8O
MW:372.4
CAS:956905-27-4
Purity:≥98% by HPLC
Appearance:White to off-white solid.
Solubility:DMSO
Long Term Storage:-20°C
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

TECHNICAL DOCUMENTS

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