PF-04217903 is a novel ATP-competitive small-molecule inhibitor of c-Met kinase. PF-04217903 displays more than 1,000-fold selectivity for c-Met compared with more than 150 kinases. PF-04217903 inhibits tumor cell proliferation, survival, migration/invasion in MET-amplified cell lines in vitro and shows marked antitumor activity in tumor models harboring either MET gene amplification or a hepatocyte growth factor (HGF)/c-Met autocrine loop at well-tolerated dose levels in vivo.
PRODUCT PROPERTIES |
Formula: | | C19H16N8O |
MW: | | 372.4 |
CAS: | | 956905-27-4 |
Purity: | | ≥98% by HPLC |
Appearance: | | White to off-white solid. |
Solubility: | | DMSO |
Long Term Storage: | | -20°C |
Background / Technical Information: | | For the Original Manufacturer's data sheet please click here. |
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