Caspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-5 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate WEHD-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase-5 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry.
|Application Notes:||For screening caspase inhibitors using fluorometric quantification.|
|Handling:||Protect from light. After reconstitution, prepare aliquots and freeze in liquid nitrogen.|
|Long Term Storage:||-20°C|
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.