Trichostatin A

Inhibitor of class I, II & IV HDACs



JBS-NU-969	1 mg	147.00 USD

Trichostatin A is a microbial (Streptomyces sp.) produced, cell permeable, potent and reversible inhibitor of HDACs. Trichostatin A inhibits in contrast to Valproic acid (#NU-968) class I,II & IV HDACs roughly to the same extent. (IC50 = 70 nM). Trichstatin A blocks cell cycle progression in G1 phase (HeLa cells), induces reversion of ras-transformed cells (NIH/3T3) to normal morphology and inhibits IL-2 gene expression (Jurkat cells).

PRODUCT PROPERTIES
Alternative Name:		4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-Oxahepta-2,4 dienohydroxamatic acid, TSA
Formula:		C₁₇H₂₂N₂O₃
MW:		302.37 g/mol
CAS:		58880-19-6
Formulation:		solid
Purity:		≥ 95 % (HPLC)
Long Term Storage:		-20°C
Miscellaneous/General:		Histone deacetylases (HDACs) are a group of enzymes involved in epigenetic regulation of gene expression. HDACs remove acetyl residues from lysine side chains of histone and non-histone proteins. They are usually components of multiprotein complexes. Inhibitors of histone deacetylases are considered as candidate drugs for cancer therapy. They alter histone acetylation and chromatin structure, which modulates gene expression, as well as promoting the acetylation of non-histone proteins.
Background / Technical Information:		For the Original Manufacturer's data sheet please click here.

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Trichostatin A

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