The saturated analog of kainic acid. Reduction of the isopropylene side-chain destroys the affinity to binding sites. It enhances the antitumor activity of doxorubicin presumably acting as a glutamate transporter inhibitor .
PRODUCT PROPERTIES |
Alternative Name: | | 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid |
Formula: | | C10H17NO4 |
MW: | | 215.25 |
CAS: | | 52497-36-6 |
Purity: | | ≥98% |
Solubility: | | Soluble in water (>110mg/mL). |
Long Term Storage: | | Ambient |
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Product Literature References
Effect of dihydrokainate on the antitumor activity of doxorubicin: Y. Sadzuka, et al.; Cancer Lett.
179, 157 (2002),
Abstract;
Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue: E.D. London, et al.; Brain Res.
192, 463 (1980),
Abstract;