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Dihydrokainic acid

NMDA agonist, GLT-1 inhibitor.
 
LKT-D3328-M010 10 mg 339.00 USD
 
LKT-D3328-M025 25 mg 771.00 USD
 
The saturated analog of kainic acid.  Reduction of the isopropylene side-chain destroys the affinity to binding sites. It enhances the antitumor activity of doxorubicin presumably acting as a glutamate transporter inhibitor .
PRODUCT PROPERTIES
Alternative Name:2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
Formula:C10H17NO4
MW:215.25
CAS:52497-36-6
Purity:≥98%
Solubility:Soluble in water (>110mg/mL).
Long Term Storage:Ambient
Formula:
lkt-d3328

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CATALOG SECTION

Antitumor Reagents Other Products
Glutamate Receptors (Ionotropic)/ R...
Glutamate Receptors (Ionotropic)/ R...
Glutamate Receptors (Ionotropic)/ R...
Glutamate Receptors (Ionotropic)/ R...

Product Literature References

Effect of dihydrokainate on the antitumor activity of doxorubicin: Y. Sadzuka, et al.; Cancer Lett. 179, 157 (2002), Abstract;
Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue: E.D. London, et al.; Brain Res. 192, 463 (1980), Abstract;
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