All Axxora Brands
Axxora Brands available in the selected country
Join Axxora
Corporate Profile
Sites
You are logged on as Guest.:  LoginRegister(Empty)
Change country
  United States
  • Home
  • Product Detail
New Products
Brands
Distributors
Support
About

Parthenolide

Sesquiterpene lactone found in Tanacetum; TRPA1 partial agonist, NLRP3 and caspase 1 inhibitor.
 
LKT-P0270-M025 25 mg 76.00 USD
 
LKT-P0270-M100 100 mg 184.00 USD
 
LKT-P0270-M250 250 mg 422.00 USD
 
Sesquiterpene lactone specifically inhibiting activation of NF-κB by preventing the degradation of IκB-α and IκB-β. Also inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2.
PRODUCT PROPERTIES
Alternative Name:(1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
Formula:C15H20O3
MW:248.32
Source:Isolated from feverfew leaves.
CAS:20554-84-1
MI:13: 7120
RTECS:LY4220000
Purity:≥98%
Solubility:DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.
Long Term Storage:+4°C
Hazard:HARMFUL.
Formula:
ALX-350-258

TECHNICAL DOCUMENTS

Print as PDF
MSDS

RELATED PRODUCTS

No related products available

PRODUCT SUPPORT

Technical Service
Bulk Quantity Quote
Customer Service

CATALOG SECTION

Natural Products - Apoptosis Induce...
Natural Products - Apoptosis Induce...
Cyclooxygenases [COX]
Cyclooxygenases [COX]
Cyclooxygenases [COX]
Other Natural Products for Inflamma...
Other Natural Products for Inflamma...
Natural Products - Anti-inflammator...
Natural Products - Signal Transduct...
MAP Kinase Pathways
MAP Kinase Pathways
MAP Kinase Pathways
NF-kB Pathway
NF-kB Pathway
NF-kB Pathway
NF-kB Pathway
NF-kB Pathway
NF-kB Pathway

Product Literature References

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide: N.M. Patel, et al.; Oncogene 19, 4159 (2000), Abstract;
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells: H.R. Wong & I.Y. Menendez; BBRC 262, 375 (1999), Abstract;
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF- kappa B by targeting the I kappa B kinase complex: S.P. Hehner, et al.; J. Immunol. 163, 5617 (1999), Abstract;
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta: S.P. Hehner, et al.; J. Biol. Chem. 273, 1288 (1998), Abstract;
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases: D. Hwang, et al.; BBRC 226, 810 (1996), Abstract;
Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta: R.W. Barsby, et al.; J. Pharm. Pharmacol. 44, 737 (1992), Abstract;
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components: H. Sumner, et al.; Biochem. Pharmacol. 43, 2313 (1992), Abstract;
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro: W.A. Groenewegen & S. Heptinstall; J. Pharm. Pharmacol. 42, 553 (1990), Abstract;
Bone Metabolism
Cancer
Cell Cycle
Cell Death / Apoptosis / Autophagy / Necrosis
Chemokines & Cytokines
Cytoskeleton
DNA & Protein Labeling
DNA Regulation / Transcription
Drug Discovery
Dyes / Stains / Fluorescent Probes
Epigenetics
Immunology
Inflammation
Molecular Biology / Genomics
Natural Products / Antibiotics
Neurobiology
Nitric Oxide Pathway
Obesity & Adipokines
Oxidative Stress
Proteasome & Related Complexes
Protein Expression / Modification
Signal Transduction
Stress & Heat Shock Proteins
Ubiquitin & Ubl Signaling
Other Products
another CS2 website
©2018 Axxora, LLC.,
  • Privacy
  • Disclaimer
  • Terms
  • Legal
  • Sitemap
  • Feedback