Parthenolide



LKT-P0270-M025	25 mg	72.00 USD

LKT-P0270-M100	100 mg	175.00 USD

LKT-P0270-M250	250 mg	402.00 USD

Sesquiterpene lactone specifically inhibiting activation of NF-κB by preventing the degradation of IκB-α and IκB-β. Also inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B₄ and thromboxane B₂.

PRODUCT PROPERTIES
Alternative Name:		(1aR-[1aR,4E,7aS,-10aS,-10bR])-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
Formula:		C₁₅H₂₀O₃
MW:		248.32
Source:		Isolated from feverfew leaves.
CAS:		20554-84-1
MI:		13: 7120
RTECS:		LY4220000
Purity:		≥98%
Solubility:		DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.
Long Term Storage:		+4°C
Hazard:		HARMFUL.

Formula:

TECHNICAL DOCUMENTS

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CATALOG SECTION

Natural Products - Apoptosis Induce...

Cyclooxygenases [COX]

Other Natural Products for Inflamma...

Natural Products - Anti-inflammator...

Natural Products - Signal Transduct...

MAP Kinase Pathways

NF-kB Pathway

Product Literature References

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide: N.M. Patel, et al.; Oncogene 19, 4159 (2000), Abstract;

Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells: H.R. Wong & I.Y. Menendez; BBRC 262, 375 (1999), Abstract;

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF- kappa B by targeting the I kappa B kinase complex: S.P. Hehner, et al.; J. Immunol. 163, 5617 (1999), Abstract;

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta: S.P. Hehner, et al.; J. Biol. Chem. 273, 1288 (1998), Abstract;

Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases: D. Hwang, et al.; BBRC 226, 810 (1996), Abstract;

Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta: R.W. Barsby, et al.; J. Pharm. Pharmacol. 44, 737 (1992), Abstract;

Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components: H. Sumner, et al.; Biochem. Pharmacol. 43, 2313 (1992), Abstract;

A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro: W.A. Groenewegen & S. Heptinstall; J. Pharm. Pharmacol. 42, 553 (1990), Abstract;