Biologically active shingolipid metabolite generated by enzymatic cleavage of stores of sphingomyelin in membranes of stimulated cells. It induces apoptosis which is associated with anhanced expression of Bax protein. Regulation of Bax gene expression by sphingosine-1-phosphate is independent of the p53 tumor suppressor.
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Product Literature References
Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product
: W.C. Hung and L.Y. Chuang; Biochem. Biophys. Res. Commun. 229
, 11 (1996), Abstract