A chlorinated tamoxifen analogue. It competes with estradiol for estrogen receptors and has growth inhibitory effects on MCF-7 breast cancer cells . It causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis .
Product Literature References
Toremifene in postmenopausal breast cancer. Efficacy, safety and cost
: J.U. Maenpaa and S.L. Ala-Fossi; Drugs Aging 11
, 261 (1997), Abstract
Apoptosis in toremifene-induced growth inhibition of human breast cancer cells in vivo and in vitro
: A.M. Warri, et al.; J. Natl. Cancer Inst. 85
, 1412 (1993), Abstract