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Troglitazone

Thiazolidinedione; PPARγ agonist, ATP-sensitive K+ channel blocker.
 
LKT-T7056-M010 10 mg 108.00 USD
 
LKT-T7056-M100 100 mg 616.00 USD
 
A novel antidiabetic agent. It is found to exert significant cell cycle arrest and apoptosis in hepatocellular carcinoma cell lines. It has a unique property of selectively inducing EGR-1 gene independent of PPARγ. Potential preventive agent for colon carcinogenesis.
PRODUCT PROPERTIES
Formula:C24H27NO5S
MW:441.54
CAS:97322-87-7
MI:13: 9838
Purity:≥97%
Solubility:Soluble in DMSO 15mg/mL, and dimethyl formide. Slightly soluble in 100% ethanol (warm).
Long Term Storage:Ambient
Formula:
270-355

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CATALOG SECTION

Apoptosis Inducers & Inhibitors Oth...
Peroxisome Proliferator Activated-R...
Peroxisome Proliferator Activated-R...
Peroxisome Proliferator Activated-R...
Antidiabetic Agents

Product Literature References

Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice: E. Osawa, et al.; Gastroenterology 124, 361 (2003), Abstract;
Troglitazone and related compounds: therapeutic potential beyond diabetes: T. Fujiwara and H. Horikoshi; Life Sci. 67, 2405 (2000), Abstract;
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