| PRODUCT PROPERTIES |
| Clone: | | PBB-1 |
| Host: | | Mouse |
| Isotype: | | IgG1 |
| Immunogen: | | Recombinant human c-Raf. |
| Species reactivity: | | Human
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| Crossreactivity: | | Does not cross-react with a-Raf or b-Raf. |
| Applications: | | WB
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| Handling: | | Avoid freeze/thaw cycles. |
| Short Term Storage: | | +4°C |
| Long Term Storage: | | -20°C |
| Miscellaneous/General: | | c-Raf is an important kinase in the transmission of extracellular stimuli to the nucleus. Mitogenic stimulation of cells induces hyperphosphorylation of c-raf in multiple serine, threonine and tyrosine residues. Phosphorylation of Ser43, Ser259 and Ser621 has been implicated in the negative regulation of raf. Phosphorylation of Ser43 interferes with ras binding, Ser259 and Ser621 represent binding sites for the 14-3-3 proteins. |
| Background / Technical Information: | | For the Original ManufacturerÂ’s Data Sheet please click here.
Our product description may differ slightly from the Original ManufacturerÂ’s Data Sheet. |
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United States
