United States
Polyclonal Antibody to TRAIL-R1 (human) (NT)
| PSC-1167-C020 | 20 µg | 87.00 USD |  |
||
| PSC-1167-C100 | 100 µg | 380.00 USD | |
||
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4) [1]. The ligand for this novel death receptor has been identified and termed TRAIL [2,3], which is a member in the TNF family.
|
FIGURES
 Figure: Western blot analysis of DR4 in HeLa (H), K562 (K), and Jurkat (J) whole cell lysate with anti-DR4 (NT) at 1:500 dilution.
|
|||||||||||||||||||||||||||||||||||||||||
General Literature References
The receptor for the cytotoxic ligand TRAIL : G. Pan, et al.; Science 276, 111 (1997), Abstract;
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB : P. Schneider, et al.; Immunity 7, 831 (1997), Abstract;
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family : R.M. Pitti, et al.; J. Biol. Chem. 271, 12687 (1996), Abstract; Full Text
Identification and characterization of a new member of the TNF family that induces apoptosis : S.R. Wiley, et al.; Immunity 3, 673 (1995), Abstract;
another CS2 website
©2019 Axxora, LLC.,
