United States
Polyclonal Antibody to FLIPγ/δ (CT)
| PSC-2055-C020 | 20 µg | 87.00 USD |  |
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| PSC-2055-C100 | 100 µg | 380.00 USD | |
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Apoptosis is related to many diseases and can also be induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and caspase-10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and c-FLIPs, respectively [1,2]. The human FLIPs were also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH, CLARP and Usurpin, respectively [3-8].
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FIGURES
 Figure: Western blot analysis of FLIPg/d in total cell lysates from HeLa (H), Jurkat (J), THP-1 (T), A431 (A), K562 (K) and NIH3T3 (N) cells with anti-FLIPg/d (CT) at 1:1000 dilution.
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Product Literature References
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex: D.M. Rasper, et al.; Cell Death Differ. 5, 271 (1998), Abstract;
Inhibition of Fas death signals by FLIPs: J. Tschopp, et al.; Curr. Opin. Immunol. 10, 552 (1998), Abstract;
CASH, a novel caspase homologue with death effector domains: Y.V. Goltsev, et al.; J. Biol. Chem. 272, 19641 (1997), Abstract; Full Text
Casper is a FADD- and caspase-related inducer of apoptosis: H.B. Shu, et al.; Immunity 6, 751 (1997), Abstract;
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis: N. Inohara, et al.; PNAS 94, 10717 (1997), Abstract; Full Text
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis: S.M. Srinivasula, et al.; J. Biol. Chem. 272, 18542 (1997), Abstract; Full Text
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95-induced apoptosis: S. Hu, et al.; J. Biol. Chem. 272, 17255 (1997), Abstract; Full Text
Inhibition of death receptor signals by cellular FLIP: M. Irmler, et al.; Nature 388, 190 (1997), Abstract;
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors: M. Thome, et al.; Nature 386, 517 (1997), Abstract;
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