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Polyclonal Antibody to FLIPγ/δ (CT)

 
PSC-2055-C020 20 µg 87.00 USD
 
PSC-2055-C100 100 µg 369.00 USD
 
Apoptosis is related to many diseases and can also be induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and caspase-10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and c-FLIPs, respectively [1,2]. The human FLIPs were also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH, CLARP and Usurpin, respectively [3-8].
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FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter proteins FADD and caspase-8 and caspase-10, and potently inhibits apoptosis induced by death receptors CD95, DR3, TRAIL-R and TNF-R1. Four splice variants of c-FLIPs have been identified and termed FLIPα, β, γ, and δ, respectively [9].
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PRODUCT PROPERTIES
Immunogen:Synthetic peptide (Prod.No. PSC-2055P) corresponding to C-terminal (aa 191-209) human FLIPδ/FLIPs form [2].
Source:From rabbit.
Species reactivity:Human, Mouse
Specificity:Recognizes FLIPγ and FLIPδ in human and mouse.
Crossreactivity:Does not cross-react with FLIPα or FLIPβ.
Applications:WB
Application Notes:Detects a band of ~25kDa and ~35kDa by Western blot.
Positive Control:Jurkat whole cell lysate (Prod. No. PSC-1205) can be used as positive control.
Blocking Peptide:For Blocking Peptide see Prod. No. PSC-2055P.
Formulation:Liquid. 100µg purified IgG in 200µl PBS containing 0.02% sodium azide.
Long Term Storage:+4°C
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

TECHNICAL DOCUMENTS

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CATALOG SECTION

FLIP
FLIP

FIGURES

PSC-2055
PSC-2055
Figure: Western blot analysis of FLIPg/d in total cell lysates from HeLa (H), Jurkat (J), THP-1 (T), A431 (A), K562 (K) and NIH3T3 (N) cells with anti-FLIPg/d (CT) at 1:1000 dilution.

Product Literature References

Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex: D.M. Rasper, et al.; Cell Death Differ. 5, 271 (1998), Abstract;
Inhibition of Fas death signals by FLIPs: J. Tschopp, et al.; Curr. Opin. Immunol. 10, 552 (1998), Abstract;
CASH, a novel caspase homologue with death effector domains: Y.V. Goltsev, et al.; J. Biol. Chem. 272, 19641 (1997), Abstract; Full Text
Casper is a FADD- and caspase-related inducer of apoptosis: H.B. Shu, et al.; Immunity 6, 751 (1997), Abstract;
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis: N. Inohara, et al.; PNAS 94, 10717 (1997), Abstract; Full Text
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis: S.M. Srinivasula, et al.; J. Biol. Chem. 272, 18542 (1997), Abstract; Full Text
I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95-induced apoptosis: S. Hu, et al.; J. Biol. Chem. 272, 17255 (1997), Abstract; Full Text
Inhibition of death receptor signals by cellular FLIP: M. Irmler, et al.; Nature 388, 190 (1997), Abstract;
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors: M. Thome, et al.; Nature 386, 517 (1997), Abstract;
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