Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were cloned [1,2]. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV) and for strains of HIV-2 and M-tropic HIV-1 [2,3].
|Alternative Name:||anti-G Protein coupled Receptor 15 (NT) PAb|
|Immunogen:||Synthetic peptide corresponding to N-terminal aa 13-28 of human G protein-coupled receptor 15 (GPR15) . The sequence differs from those of African green monkey and pig-tailed macaque BOB by one amino acid .|
|Species reactivity:||Human, Mouse, Rat|
|Application Notes:||Detects a band of ~50kDa by Western blot. |
|Positive Control:||Jurkat whole cell lysate (Prod. No. PSC-1205) or A549 whole cell lysate (Prod. No. PSC-1203) can be used as positive control.|
|Blocking Peptide:||For Blocking Peptide see Prod. No. PSC-2101P.|
|Formulation:||Liquid.100µg purified rabbit IgG in 200µl PBS containing 0.02% sodium azide.|
|Long Term Storage:||+4°C|
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.
Figure: Western blot analysis of GPR15 in human heart lysate with anti-GPR15 (NT) in the absence (lane 1) or presence of specific peptide (lane 2) or non-related peptide (lane 3).
Product Literature References
Expression cloning of new receptors used by simian and human immunodeficiency viruses
: H.K. Deng, et al.; Nature 388
, 296 (1997), Abstract
Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection
: M. Farzan, et al.; J. Exp. Med. 186
, 405 (1997), Abstract
; Full Text
A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3
: M. Heiber, et al.; Genomics 32
, 462 (1996), Abstract