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Polyclonal Antibody to IKKα (human) (C3)

 
PSC-2117-C020 20 µg 87.00 USD
 
PSC-2117-C100 100 µg 380.00 USD
 
Nuclear factor kappa B (NF-κB) is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories [1-5]. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα [IKK1] and IKKβ [IKK2] interact with each other and both are essential for the NF-κB activation.
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IKKα specifically phosphorylates IκB-α. IKKα is expressed in a variety of human tissues.
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PRODUCT PROPERTIES
Alternative Name:Inhibitor of Nuclear Factor κ-B Kinase α, IKK1
Host:Rabbit
Immunogen:Synthetic peptide corresponding to aa 658-674 (C658TQSSARSLVGSSLEGA674) of human IKKα (inhibitor of NF-κB kinase α; IKK1).
Species reactivity:Human
Crossreactivity:Does not cross-react with IKKβ or IKKγ.
Applications:WB
Application Notes:Detects a band of ~85kDa by Western blot.
Positive Control:Jurkat whole cell lysate (Prod. No. PSC-1205) can be used as positive control.
Blocking Peptide:For Blocking Peptide see Prod. No. PSC-2117P.
Formulation:Liquid. 100µg purified rabbit IgG in 200µl PBS containing 0.02% sodium azide.
Long Term Storage:+4°C
Background / Technical Information:For the Original Manufacturer's data sheet please click here.

TECHNICAL DOCUMENTS

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CATALOG SECTION

NF-kB Pathway
NF-kB Pathway
NF-kB Pathway
IkB Kinases [IKKs]
NF-kB Pathway
NF-kB Pathway
NF-kB Pathway
IkB Kinases [IKKs]

FIGURES

PSC-2117
PSC-2117
Figure: Western blot analysis of IKKa in HeLa whole cell lysate with anti-IKKa (C2) at 1:500 dilution.

Product Literature References

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB: J.A. DiDonato, et al.; Nature 388, 548 (1997), Abstract;
Identification and characterization of an IkappaB kinase: C.H. Regnier, et al.; Cell 90, 373 (1997), Abstract;
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK: J.D. Woronicz, et al.; Science 278, 866 (1997), Abstract;
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation: F. Mercurio, et al.; Science 278, 860 (1997), Abstract;
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation: E. Zandi, et al.; Cell 91, 243 (1997), Abstract;
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