United States
Polyclonal Antibody to IKKα (human) (C3)
| PSC-2117-C100 | 100 µg | 347.00 USD |  |
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Nuclear factor kappa B (NF-κB) is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories [1-5]. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα [IKK1] and IKKβ [IKK2] interact with each other and both are essential for the NF-κB activation.
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FIGURES
 Figure: Western blot analysis of IKKa in HeLa whole cell lysate with anti-IKKa (C2) at 1:500 dilution.
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Product Literature References
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB: J.A. DiDonato, et al.; Nature 388, 548 (1997), Abstract;
Identification and characterization of an IkappaB kinase: C.H. Regnier, et al.; Cell 90, 373 (1997), Abstract;
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK: J.D. Woronicz, et al.; Science 278, 866 (1997), Abstract;
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation: F. Mercurio, et al.; Science 278, 860 (1997), Abstract;
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation: E. Zandi, et al.; Cell 91, 243 (1997), Abstract;
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