Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors. Several novel members in the TNF-R family including DR3, TRAIL-R1 (DR4), TRAIL-R2 (DR5), and DR6 were discovered and function as death receptors. Two putative decoy receptors, TRAIL-R3 and TRAIL-R4, were identified to compete with TRAIL-R1 and TRAIL-R2 for their ligand TRAIL binding. A novel decoy receptor was discovered and designated DcR3 and TR6, respectively [1,2].
|Alternative Name:||Polyclonal Antibody to TR6 (NT), anti-TNFRSF 6B PAb (NT)|
|Immunogen:||Synthetic peptide (PSC-2140P) corresponding to N-terminal (aa 31-46) human TR6 precursor [1,2].|
|Specificity:||Recognizes human, mouse and rat TR6. Detects a band of ~33kDa by Western blot.|
|Application Notes:||Western blot (dilution 1:500-1:1000).|
|Positive Control:||Human heart tissue lysate (Prod. No. PSC-1301) can be used as positive control.|
|Blocking Peptide:||For Blocking Peptide see Prod. No. PSC-2140P.|
|Formulation:||Liquid. 100µg purified rabbit IgG in 200µl PBS containing 0.02% sodium azide.|
|Background / Technical Information:||For the Original Manufacturer's Data Sheet please click here.|
Our product description may differ slightly from the Original Manufacturer's Data Sheet.
Figure: Western blot analysis of DcR3 in human heart (H), brain (B), and kidney (K) tissue lysates with anti-DcR3 (NT) at 1:500 dilution.
Product Literature References
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
: K.Y. Yu, et al.; J. Biol. Chem. 274
, 13733 (1999), Abstract
; Full Text
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
: R.M. Pitti, et al.; Nature 396
, 699 (1998), Abstract