United States
Polyclonal Antibody to CX3CR1
| PSC-2201-C020 | 20 µg | 87.00 USD |  |
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| PSC-2201-C100 | 100 µg | 358.00 USD | |
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CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3 R1, and RBS11, respectively [1-4]. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 [5]. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine [6].
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FIGURES
 Figure: Immunohistochemistry of CX3CR1 in human spleen cells with CX3CR1 antibody at 10μg/ml.
 Figure: Western blot analysis of CX3CR1 in THP-1 cell lysate in the absence (lane A) or presence (lane B) of blocking peptide with anti-CX3CR1 (EL) at 1:500 dilution.
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Product Literature References
Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine: C. Combadiere, et al.; BBRC 253, 728 (1998), Abstract;
Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.: C. Combadiere, et al.; J. Biol. Chem. 273, 23799 (1998), Abstract; Full Text
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion: T. Imai, et al.; Cell 91, 521 (1997), Abstract;
Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene: C. Combadiere, et al.; DNA Cell Biol. 14, 673 (1995), Abstract;
The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues: C.J. Raport, et al.; Gene 163, 295 (1995), Abstract;
cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors: J.K. Harrison, et al.; Neurosci. Lett. 169, 85 (1994), Abstract;
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