Polyclonal Antibody to CX3CR1



PSC-2201-C020	20 µg	87.00 USD

PSC-2201-C100	100 µg	358.00 USD

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3 R1, and RBS11, respectively [1-4]. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 [5]. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine [6].

PRODUCT PROPERTIES
Alternative Name:		anti-CX3C Chemokine Receptor-1 PAb, anti-V28 PAb, anti-CMKBRL1 PAb
Host:		Rabbit
Immunogen:		Synthetic peptide corresponding to aa 175-189 of the extracellular loop of human CX3C chemokine receptor 1 (CX3CR1).
Species reactivity:		Human, Mouse, Rat
Applications:		IHC, WB
Application Notes:		Detects a band of ~50kDa by Western blot.
Positive Control:		THP-1 whole cell lysate (Prod. No. PSC-1208) can be used as positive control.
Blocking Peptide:		For Blocking Peptide see Prod. No. PSC-2201P.
Formulation:		Liquid. 100µg purified IgG in 200µl PBS containing 0.02% sodium azide.
Long Term Storage:		+4°C
Background / Technical Information:		For the Original Manufacturer's Data Sheet please click here. Our product description may differ slightly from the Original Manufacturer's Data Sheet.

TECHNICAL DOCUMENTS Print as PDF	RELATED PRODUCTS THP-1 Whole Cell Lysate Blocking Peptide for PAb to CX3CR1 ...
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FIGURES

Figure: Immunohistochemistry of CX3CR1 in human spleen cells with CX3CR1 antibody at 10μg/ml.

Figure: Western blot analysis of CX3CR1 in THP-1 cell lysate in the absence (lane A) or presence (lane B) of blocking peptide with anti-CX3CR1 (EL) at 1:500 dilution.

Product Literature References

Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine: C. Combadiere, et al.; BBRC 253, 728 (1998), Abstract;

Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.: C. Combadiere, et al.; J. Biol. Chem. 273, 23799 (1998), Abstract; Full Text

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion: T. Imai, et al.; Cell 91, 521 (1997), Abstract;

Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene: C. Combadiere, et al.; DNA Cell Biol. 14, 673 (1995), Abstract;

The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues: C.J. Raport, et al.; Gene 163, 295 (1995), Abstract;

cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors: J.K. Harrison, et al.; Neurosci. Lett. 169, 85 (1994), Abstract;

Polyclonal Antibody to CX3CR1

TECHNICAL DOCUMENTS

RELATED PRODUCTS

PRODUCT SUPPORT

CATALOG SECTION

FIGURES

Product Literature References