| PRODUCT PROPERTIES |
| Alternative Name: | | Tek (human):Fc (human), Soluble (recombinant), CD202b (human):Fc (human), Soluble (recombinant) |
| MW: | | ~250kDa. |
| Source: | | Disulfide-linked glycosylated homodimer produced in insect cells. Recombinant human soluble Tie-2 is fused to the Fc portion of human IgG1. |
| EC: | | 2.7.1.112 |
| Formulation: | | Lyophilized from PBS. |
| Purity: | | ≥90% (SDS-PAGE) |
| Endotoxin Content: | | ≤1.2EU/µg protein. |
| Biological Activity: | | Binds recombinant human Ang-2 (angiopoietin-2). |
| Solubility: | | Soluble in water and most aqueous buffers. |
| Reconstitution: | | Reconstitute with PBS or medium (>50µg/ml). |
| Long Term Storage: | | -20°C |
| Handling: | | After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
| Background / Technical Information: | | For the Original Manufacturer’s Data Sheet please click here.
Our product description may differ slightly from the Original Manufacturer’s Data Sheet.
Swiss-Prot link Q02763: Tie-2 (human) (precursor)
AfCS Signalling Gateway link A002283: Tie-2 (mouse) |
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Product Literature References
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development: N.W. Gale & G.D. Yancopoulos; Genes Dev.
13, 1055 (1999),
Abstract;
Full Text
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system: T.N. Sato, et al.; PNAS
90, 9355 (1993),
Abstract;
Full Text
United States
