Actinomycin D |  | | SYNONYMS | Actinomycin IV
Actinomycin C1
Dactinomycin | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antitumor Antibiotics | | | | | Product Specification | | |
| FORMULA: | C62H86N12O16 | | | | | |
| MW: | 1255.5 | | | | | |
| CAS NUMBER: | 50-76-0 | | | | | |
| MERCK INDEX: | 14: 2800 | | | | | |
| RTECS: | AU1575000 | | | | | |
| SOURCE/HOST: | Isolated from Streptomyces parvulus. | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | Red shiny crystals. | | | | | |
| SOLUBILITY: | Soluble in DMSO, 100% ethanol or methanol. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| USE/STABILITY: | Sensitive to strong acids and bases. | | | | | |
| HANDLING: | Hygroscopic. Protect from light. | | | | | |
| HAZARD: | VERY TOXIC. | | | | | | Product Description | Antitumor antibiotic. DNA intercalating agent. Cytotoxic inducer of apoptosis against tumor cells. Inhibitor of RNA synthesis.
For nomenclature see S.A. Waksman, E. Katz & L.C. Vining; PNAS 44, 602 (1958)
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| | | Product Specific Literature References | Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle: J.M. Glynn, et al.; Biochem. Soc. Trans. 20, 84S (1992) Abstract
Influence of DNA base sequence on the binding energetics of actinomycin D: S.A. Bailey, et al.; Biochemistry 32, 5881 (1993) Abstract
Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice: M. Akahori, et al.; J. Surg. Res. 85, 286 (1999) Abstract
Tumor necrosis factor-alpha plus actinomycin D-induced apoptosis of L929 cells is prevented by nitric oxide: S. Hakoda, et al.; Surg. Today 29, 1059 (1999) Abstract
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells: J. Kleeff, et al.; Int. J. Cancer 86, 399 (2000) Abstract
Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity: C. Qing, et al.; Acta Pharmacol. Sin. 24, 415 (2003) Full Text; http://www.chinaphar.com/1671-4083/24/415.pdf
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II: H.E. Mischo, et al.; J. Biol. Chem. 280, 9586 (2005) Abstract
Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes: I. Kalousek, et al.; Anticancer Drugs 18, 763 (2007) Abstract
Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M.J. Wang, et al.; Neurosci. Res. 59, 40 (2007) Abstract |
| | | | Related Products | | | | 7-Amino-actinomycin D | |
| | | | RELATED PRODUCT GROUPS | Cancer > Antitumor Reagents > Antitumor Agents (Apoptosis Inducers) / DNA Regulation / Transcription > Transcription Inhibitors / Related Products / Natural Products / Antibiotics > Antibiotics > Antibiotics - Apoptosis Inducers & Inhibitors | | | | | |
