Apamin |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | K+ Channel Blockers & Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-151-013-MC05 |
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0.5 mg | | | | | | | | Replaces Prod. #: BML-KC150 |
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| Product Specification |
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| SEQUENCE: | H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15) |
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| FORMULA: | C131H131N31O24S4 |
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| MW: | 2027.3 |
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| CAS NUMBER: | 24345-16-2 |
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| MERCK INDEX: | 14: 725 |
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| RTECS: | CD6899900 |
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| SOURCE/HOST: | Synthetic. |
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| PURITY: | ≥93% (HPLC) |
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| APPEARANCE: | Lyophilized. |
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| SOLUBILITY: | Soluble in 0.05M acetic acid (5mg/ml); slightly soluble in water (1mg/ml). |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HAZARD: | VERY TOXIC. |
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| Product Description |
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker. |
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| | Product Specific Literature References | Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle.: A.L. Blatz & K. L. Magleby; Nature 323, 718 (1986) Abstract
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.: M. Hugues et al.; PNAS 79, 1308 (1982) Abstract
GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.: A. Tse et al.; Science 255, 462 (1992) Abstract |
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| RELATED PRODUCT GROUPS |
Peptides |
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