Ansatrienin A |  | | SYNONYMS | Mycotrienin I
T 23I | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antitumor Antibiotics | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-203-M001 |
|
1 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C36H48N2O8 | | | | | |
| MW: | 636.8 | | | | | |
| CAS NUMBER: | 82189-03-5 | | | | | |
| RTECS: | AY4553220 | | | | | |
| SOURCE/HOST: | Isolated from Streptomyces collinus. | | | | | |
| PURITY: | ≥97% (HPLC) | | | | | |
| APPEARANCE: | Yellow powder. | | | | | |
| SOLUBILITY: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | TOXIC. | | | | | |
| IDENTITY: | Identity determined by 1H-NMR. | | | | | | Product Description | Antitumor antibiotic, closely related to the cytotrienins. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption. |
| | | Product Specific Literature References | Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Full Text; http://www.jbc.org/cgi/content/full/270/43/25949 |
| | | | | RELATED PRODUCT GROUPS | Bone Metabolism > Bone Metabolism Other Products | | | | | |
