Ac-DEVD-AMC |
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| SYNONYMS | Caspase-3 Substrate (Fluorogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-031-M001 |
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1 mg | | | | | ALX-260-031-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Asp-Glu-Val-Asp-AMC (AMC = 7-Amino-4-methylcoumarin) |
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| FORMULA: | C30H37N5O13 |
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| MW: | 675.7 |
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| PEPTIDE CONTENT: | 70-95% |
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| PURITY: | ≥97% (HPLC) |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in DMSO. Dilute with buffer, pH 7.5. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Protect from light. |
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| Product Description |
Fluorogenic substrate for caspase-3. Also a substrate for caspase-1, -4, -7 and -8. The peptide sequence is based on the PARP cleavage site Asp216 for caspase-3. |
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| | Product Specific Literature References | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo, et al.; Cell Death Differ. 6, 362 (1999) Abstract |
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| | General Information | |
Background/Technical Information | | AMC has an excitation maximum of 380nm and an emission maximum of 460nm. | | |
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| RELATED PRODUCT GROUPS |
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