Ac-YVAD-AMC |
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| SYNONYMS | Caspase-1 Substrate (Fluorogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-024-M001 |
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1 mg | | | | | ALX-260-024-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Tyr-Val-Ala-Asp-AMC (AMC = 7-Amino-4-methylcoumarin) |
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| FORMULA: | C33H39N5O10 |
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| MW: | 665.7 |
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| PEPTIDE CONTENT: | 75-95% |
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| PURITY: | ≥99% (HPLC) |
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| APPEARANCE: | White to off-white powder. |
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| SOLUBILITY: | Soluble in DMSO. Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES). |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Keep cool and dry. |
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| Product Description |
Fluorogenic substrate for caspase-1. |
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| | Product Specific Literature References | A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Interleukin-1 β converting enzyme: N.A. Thornberry; Meth. Enzymol. 244, 615 (1994) Abstract
Crystal structure of the cysteine protease interleukin-1 β-converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract |
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| | General Information | |
Background/Technical Information | | AMC has an excitation maximum of 380nm and an emission maximum of 460nm. | | |
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| RELATED PRODUCT GROUPS |
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