Ac-DEVD-CHO |
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| SYNONYMS | Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-030-M001 |
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1 mg | | | | | ALX-260-030-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Asp-Glu-Val-Asp-CHO |
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| FORMULA: | C20H30N4O11 |
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| MW: | 502.5 |
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| PEPTIDE CONTENT: | 70-90%. |
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| PURITY: | ≥95% (HPLC) |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in distilled water or DMSO. |
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| RECONSTITUTION: | Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture. |
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| HANDLING: | Keep cool and dry. Keep under nitrogen. |
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| Product Description |
Reversible inhibitor of caspase-3 and -7. |
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| | Product Specific Literature References | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996) Abstract
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis: D.W. Nicholson; Nature Biotechnol. 14, 297 (1996) Abstract
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis: J. Schlegel, et al.; J. Biol. Chem. 271, 1841 (1996) Full Text; http://www.jbc.org/cgi/reprint/271/4/1841.pdf
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Full Text; http://www.jbc.org/cgi/reprint/272/20/13432.pdf
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998) Full Text; http://www.jbc.org/cgi/reprint/273/49/32608.pdf
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999) Full Text; http://www.biochemj.org/bj/340/0127/bj3400127.htm |
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